I meant that the known mechanism that you have mentioned does not explain all its reported benefits. Specifically in the anti-inflammatory effect, it seems like inhibition of prostaglandin synthesis (via COX enzyme binding) is not the reason[1].
As aspirin has so many potential benefits, it seems to me that it has to have some effect in some very basic and common site and the mitochondrial respiratory chain is a good, if not best, candidate.
If you are interested in uncoupling and free radical production, Peter[2] has a good amount of info about it.
At any rate, aspirin has many knowns unkowns; that´s what I meant in my original post.
I meant that the known mechanism that you have mentioned does not explain all its reported benefits. Specifically in the anti-inflammatory effect, it seems like inhibition of prostaglandin synthesis (via COX enzyme binding) is not the reason[1].
As aspirin has so many potential benefits, it seems to me that it has to have some effect in some very basic and common site and the mitochondrial respiratory chain is a good, if not best, candidate.
If you are interested in uncoupling and free radical production, Peter[2] has a good amount of info about it.
At any rate, aspirin has many knowns unkowns; that´s what I meant in my original post.
[1] http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2213311/
[2] http://high-fat-nutrition.blogspot.com.es/