I don't know if it will solve your particular problem, but I would suggest trying PlayOnLinux. It saved me from having a lot of hassle having different Wine configurations and versions side by side.
Yeah, I do use playonlinux for reasons like this, but to me it's a bit of a bandaid to the pace of patch acceptance to the wine project. Don't get me wrong, in spite of that the wine project moves at an amazing pace, but working fixes sit on their bug tracker for months and months before being integrated into the mainline.
But the mixed 32bit/64bit thing is just a fundamentally broken part of wine that got seems to have gotten turned on by default before it was ready. It makes wine look bad.
