Absolutely. Build it, and I will come. HN is awesome for its variety of startup/programming related news but I would love to see a site dedicated to nothing but programming, front-end(html/css/javascript), and science news. Would you even consider curating the content somewhat? Definitely have a voting system in place, but be compelled to remove content that doesn't match the purpose of the site.
We plan to aggressively (but openly) moderate submissions. Another idea we were kicking around was instead of using forms to submit comments or stories, you would do it solely via the API.