Concur on most interesting! I really hope it works out, but am cautious.
It is surprising to me seeing the rust web backend scene; many libraries, server frameworks, and users, but they are all Flask-analogs, without the benefit of the reasonably-robust ecosystem Flask has. My suspicion is that people are using them for micro-services and not websites/webapps, but I haven't been able to get a straight answer on this about how people are using these tools. I.e. even though rust is my favorite overall language and see no reason it couldn't be used for web work, I still use Django.
Axos, Axum, Rocket, Diesel etc, are all IMO not in the same league as Django. My understanding is that addressing this is Loco's Raison d'etre.
Another aspect of the Rust web ecosystem: It's almost fully gone Async.
I'll say this, coding agents make the lack of a "batteries included" framework like rails or Django somewhat less daunting.
But "convention over code" and having a default structure / shape for projects is extremely helpful and you feel it when it's missing.
For my last small project I looked at Loco but ended up passing on it because I felt like adoption wasn't great yet. I really hope it takes off, though.
It's really hard to get away from ssjs frameworks for front-end, so for my startup it's Axum + Seaorm for "the api" and a Svelte SSR "front end" / view layer.
I think rust programers are more likely to want flask/rack than Django/rails.
I'm at a point now where I'm not even a little interested in new frameworks. I want tried and tested. Preferably something that has been around for 15 years.
Loco follows up the Rails formula pretty closely, and makes easier to learn Rust by taking care of a load of boilerplate code.