I worked on a highly unsuccessful multi-billion dollar health system that was intended to solve all of these problems on a national level. I can tell you now that a small guy working from the bottom up with individual institutions is much better placed to solve real problems than a top-down bureaucracy. The only hurdle is convincing them that they can trust your system with confidential and life-critical data.
I work at a highly successful company thats working to solve some of the problems the health care industry faces(mainly the elder care community). We grow by 20% annually and we have goals of 28% when we only grow by 26 as opposed to 28 we see it as bad.
And yes the rules, and crazy laws, and hand waving are very very apparent. Its insane but we make plenty of money.
I'm a one-man startup working to solve problems in the clinical trial and research space. The sheer number of problems can be somewhat distracting and the rules daunting, but there are a lot of doctors out there with money to throw at solutions. It is amazing.
Am I profitable? Not yet. Obviously, I'm missing some necessary traits (read: co-founder.)
Where there is fear, there are opportunities.