It would be a game changer for anyone involved with manufacturing layout for solid objects at any level of business. I've personally used my own perspective from playing Factorio to influence real world factory design. It's a great way to strengthen intuition that complements knowledge and theory.
Phil Salvador wrote an article about the long lost SimRefinery by Maxis Business Simulations, and somebody who read it was able to dig up a floppy disk with the original game!
When SimCity got serious: the story of Maxis Business Simulations and SimRefinery