Science fiction beat the author of this article to the punch re: novel cooling solutions in space. The author proposes squirting oil from one arm, through open vacuum, to another arm - the oil droplets radiate the heat en route from arm 1 to arm 2. However, like most modern tech, science fiction writing has anticipated it. In the book Saturns Run (2015), by John Stanford and Ctien, their spaceship cools down it's megawatt nuclear reactor by using a eutectic metal as coolant, which runs as a molten ribbon through open vacuum from arm 1 to arm 2.
My take is also a missile, but as an interceptor, not offensive purposes. North Korea has shown that they can deliver a payload to Japan if they want. If the NKs do decide to launch something at Japan, it's not going to be tipped with conventional explosives. It'll be a nuke. Hypersonic interceptor seems the more likely application is this tech to me.
I think that hypersonic interceptors would use a rocket motor and not a ramjet, but I'm not sure.
I think this is for offence because I understood the advantage of this engine (compared to a rocket engine) is that you don't carry oxygen so you can carry more fuel and get more range. I think range is much more useful for offence than defence.
I am possibly making myself look foolish now as I'm not an expert on either rockets or ramjets and I might have incorrectly dismissed defensive applications.
Long-time ebay seller here. I'm seeing comments floating towards the top that are essentially positing that the physical GameStop locations can be used as hubs where people can buy or sell their stuff in general (especially items that are 'pick-up only'). A pawn shop, basically.
Thing is, GameStop is, well, for videogames and videogame paraphernalia. It's not a general store. Doing this would turn them into a thrift shop, not a pawn shop, as people are trying to offload their carpets, desks, etc - bulky stuff.
I don't think this makes sense.
This does make sense when you consider the collectable market, another domain I'm involved in. Trading card games, specifically pokemon, have exploded over the last 5 years. GameStop is making a killing off of buying, selling, and grading these cards. Ebay is the primary marketplace to buy and sell those cards. There's also tax free havens ("Vaults") offered by multiple companies, grading service passthroughs, and scalping offered through ebay too.
Viewed through the above lens, that's what's prompting this offer, I think.
I think a lot of people are missing that eBay bought TCG Player back in 2022. This would fold the TCG Player brand into GameStop. Many (most?) local game stores list their inventory on TCG Player. In addition to the physical stores themselves, GameStop would have their hand in nearly every digital trading card transaction. GameStop would own the TGC Player warehouses and inventory.
> They paid a total of 2 people $50,000 (edit: in 2016 dollars). That doesn't seem like enough to entirely shape worldwide discourse around nutrition and sugar.
You would be astonished at how little it takes to bribe, I mean donate, to a politician for example. For as little as $10-20k USD you can get a literal seat at a table with a sitting senator or congresscritter for several hours at a "charity" dinner, with results as expected.
You are absolutely bonkers. This post and the rationale behind it are beyond insane.
We do not understand these ecosystems beyond their extreme fragility and low entropy conditions. This is an incredibly destructive and expensive manner of resource extraction that destroys the seabed. Why would anyone sane ever support this beyond, I don't know, someone who also thinks that clearcutting the amazon is a good idea? What kind of vested interest do you have in this blighted technology?
Sorry, as someone in this field, this is bullshit. It is in mice.
Several things trigger my bullshit meter. Quote:
"This dramatically surpasses the therapeutic efficacy of current standard treatments, including immune checkpoint inhibitors (anti-PD-L1 antibody) and liposomal doxorubicin (chemotherapy agents)"
PD-L1 monoclonal antibodies are only effective against cancers that are, you guessed it, PD-L1 positive. At high percentages, ranging from 1 to 50%. Are these authors even familiar with the state of the art when it comes to cancer medications? Mouse tumors do not equate to people tumors. Many tumor types are not PD-l1 positive.
Doxy is an ancient SOC chemo.
This is a nothing burger.
Give me phase II/III clinical trials, and then let me know what their PFS/OS was after 5 years. and what the medians were at 3- and 5-years. Also, ORR and CR and needed.
CAR-T is ahead of the game, and will be the ultimate winner here as it grows to scale.
In my dad’s case- he had gastric melonama. We surgically removed it and as consolidation We administered pd-L1 Immune checkpoint inhibitor. Melonama recurred again in 6 months time. This time in esophagus.
As an engineer I think all drugs tested and efficacies studied are on statistically not so significant data points. Given the permutations and combinations far exceed the clinical trials available and hence everything post clinical trial is also just an extended trial.
Wonder How to fix this? I am assuming heLa cells etc are also not the right test setup to have better test results.
Keytruda, pembrolizumab, (what he probably received) can only do so much. If it was in his GI tract it was also elsewhere in multiple places. The PD-L1 drugs at this point have more than 400k patients treated, with decent efficacy. I'm sorry for your loss. If his melanoma had metastasized to his GI tract it was too late for anything except palliative care.
This drug has been used in a huge number of patients for more than 11 years; the next gen of drugs is currently being used. I'm sorry for my curt style of writing, but - people like your father have helped pave the way for that next generation of drugs by constraining clinical trial designs.
Nivumolab was the drug administered in adjuvant setting.
Maybe you are right that 400k patient with decent efficacy - however pegged chances are about 70-80% and not 100. So my point is can there be a better test bench to try and inch closer to a better efficacy?
For example - if hela cells can be used for trials — can there be the cultured tissue be used instead of mice as day 1?
Also curious — how did the scientist decide on using a specific cell/protein to be used for checking if this is producing results. Is it a hunch or science ?
Seems like a very interesting approach, even if it’s early stage.
> Many tumor types are not PD-l1 positive.
> Doxy is an ancient SOC chemo. This is a nothing burger.
Meh the research didn’t say those were state of the art, but that they were “common” treatments. In other words a baseline for a presumably cheap and well studied animal surrogate.
> CAR-T is ahead of the game, and will be the ultimate winner here as it grows to scale.
Last I read up on it last year CAR-T treatments struggled with solid mass tumors.
Many cancers don’t have unique proteins for CAR-T to target (similar to the pd-l1 issue).
Then CAR-T struggles getting the modified T cells into the solid mass tumors en masse. Interestingly this approach actually makes use of the tumor environment rather than be hindered by it.
> Sorry, as someone in this field, this is bullshit. It is in mice.
Nice to hear an expert opinion. Let's hope your comment goes back to black. I have a lot of question!
> This is a nothing burger.
Is it enough for a bread-mayo-bread sandwich? Lettuce?
IIUC the bacteria makes the cancer disappear for two weeks, until they end the study and kill the mice. (IIUC this is timeline is usual for very early studies.) They tried other bacterias and one of them made the cancer disappear for a few days, so I'm worried about the long time efficiency of this method.
Is injecting the bacterias a second time as efficient as the first time, or the inmune system kills the bacteria before they hurt the cancer?
What happen in case of metastasis? Each one must be injected with the bacterias or they will jump and make all of them disappear?
Does the bacteria infect other organs and kill you? Is there a good antibiotic in case the bacteria cause problems?
They used cancers that were 200mm3 (i.e. like a sphere of 7mm = 1/4 inch). What happens in bigger cancers? Does bigger cancer have better irrigation and make it more difficult for the bacteria to survive? What happens to tiny hidden metastasis (that probably still have good enough irrigation)?
I feel like many of the comments are focused on the trees and not on the forest. The new head of Facebook AI is 28 years old? That's not OK, that's too young. Too inexperienced and not worldwise enough by a long shot. No shit they're having problems. Can you imagine being a facebook lifer, or one of the LLM pros they've bribed/hired over to the company, to be bossed around by someone with very little life experience? No shit it isn't going well.
That’s much older than when Zuckerberg founded Facebook. Also older than when Bill Gates founded Microsoft, Steve Jobs founded Apple, and Larry Page and Sergey Brin founded Google. We’re talking about running a tech company, not being a politician. Clearly there’s no need to be 50+ and have a bunch of “life experiences” to be successful.
When these companies were founded, they had nowhere near the scale and resources in the hands of the current set of folks. Zuckerberg at 28 was riding a bike and this is a rocketship (pointed up or down, is not clear)
> The new head of Facebook AI is 28 years old? That's not OK, that's too young. Too inexperienced and not worldwise enough by a long shot.
This is ageist in the way I don't usually expect from the Valley. Plenty of entrepreneurs have built successful or innovative concepts in their 20s. It is OK to state that Wang is incompetent, but that has little to do with his age and more to do with his capability.
The only benefit as I perceive it re: orbital data center hardware is regulatory avoidance. Think...DDOS machines that can't be shut off; or financial hosting services for unsavory individuals. However, it's very expensive by all metrics (including those talked about in the article), and frankly, these satellites are sitting ducks for the hunter killer satellites the various space powers have, if they actually wanted to do something about these hypothtical data centers and the problems they would cause.
I don't see how this is really much different from just setting up servers in some underregulated banana republic; to do anything, you still need a connection to the public internet, and somewhat regulated nations like the EU or US can just block/prosecute at that interface.
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